Being part of MADE
The Minocycline in Alzheimer’s Disease Efficacy (MADE) trial is a new study coming onto ‘Join dementia research’. MADE is a multi-centre, randomised, controlled trial in very mild Alzheimer’s Disease. It aims to determine whether the antibiotic Minocycline is effective in reducing the rate of cognitive and functional decline over a 2-year period and assess the safety and tolerability of Minocycline.
We took time to hear from Wendy Mitchell who is currently participating in the trial.
When did you first get involved in the MADE trial?
About 2-3 months ago.
How did you originally hear about it?
Originally, I was looking for research to take part in. I found there was the MADE trial where I receive treatment at my memory clinic, but they didn’t offer me the opportunity to take part in the research; I had to ask them if there was any research going, and so that’s how I came to take part.
Then they let you take part?
Yes; obviously after a screening process. Initially I had to do the basic, mini mental test, to make sure that my score was in the correct range. Then I had someone from the team come to the house to talk about the trial, and take me through what would happen to make sure that I was fully informed on what would go on.
Why did you want to take part in research?
Well, to take part in research is a no brainer for me. Taking part in research, I can give my daughters some hope for the future. Obviously we have no cure at the moment, so taking part in research just gives me that feeling of doing something positive for future generations.
Why the MADE trial in particular?
This one in particular because it was local; and because it was the first one that I actually fitted the criteria to take part in, so I just jumped at the chance to. And the MADE trial sounded like a logical trial because it’s medication that already exists, which seems like a very good way for research to go down, to actually test current medications to see if they can not only impact on what they’re currently manufactured for but also to see if they can help other diseases as well.
Minocycline, which is part of the MADE trial, is currently used as a drug, an antibiotic for the treatment of acne, but they believe it could reduce inflammation on the brain, so they are wondering if it could impact on people with Alzheimer’s. That seems like a very logical reason for taking part, and a logical reason for trialling this drug as well.
What does the trial involve you doing?
You take the medication twice a day. You are randomly selected to receive one of three treatments. So there is the chance that you could have the placebo, the other two are you could be taking 200mg of Minocycline per day or 400mg. You don’t know which of those three treatments you are on, and no one does apart from the randomisation office.
You are supplied with two cartons labelled A and B, and you have to take one capsule from each carton in the morning and one capsule from each carton in the evening. You are initially given three months’ supply of the tablets, and you are rang quite regularly to check whether you have any side effects, which is always reassuring. You are well looked after when you’re taking part in trials.
Your GP’s informed because there is an antibiotic that you can’t take while you’re on these tablets. Everything seems to be well looked after and everybody’s well informed on what’s going on while you are in the trial. Before you start the trial, you have a blood test and general questions are asked about your health, and similar checks are done every three months. So you are constantly under observation during the trial. You also have a person that you can contact; you have a telephone number and a named person if you have any problems. You also receive a hand out with everything you need to know before you start the trial.
Do you have to go into a local hospital for those check-ups?
No, they come to you.
To see if you are eligible, please sign up for ‘Join dementia research’ and enter all your information required.
Have you been involved in a study on the service? What did you learn? If you are interested in telling your story, please get in touch (firstname.lastname@example.org).